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Regulation of Mhc Class I by Dengue Virus: an Update on Dengue Immunopathogenesis
Shatrah Othman
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Regulation of Mhc Class I by Dengue Virus: an Update on Dengue Immunopathogenesis
Shatrah Othman
Despite aggressive efforts in dengue research, the control of dengue diseases and discovery of therapeutics against them await complete elucidation of its complex immune-pathogenesis. Virtually all mammalian cells express surface major histocompatibility complex class I (MHC Class I) molecules which are crucial for immune recognition and MHC-restricted cytolysis as part of the adaptive immune response. In contrast to many viruses that escape this host?s immune responses by suppressing the MHC Class I pathway, infections by Flaviviruses, such West Nile virus, have been associated with a virus-specific increase of these antigen-presenting molecules. This study presents evidence of MHC Class I gene modulation by dengue virus, hence providing a better understanding of dengue immunopathogenesis that would consequently facilitate the discovery of antiviral therapeutics against dengue.
Media | Böcker Pocketbok (Bok med mjukt omslag och limmad rygg) |
Releasedatum | 2 augusti 2012 |
ISBN13 | 9783848495238 |
Utgivare | LAP LAMBERT Academic Publishing |
Antal sidor | 204 |
Mått | 150 × 12 × 226 mm · 303 g |
Språk | Engelska |
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